Vice President Clinical Development #4979

Our mission is to detect cancer early, when it can be cured. We are working to change the trajectory of cancer mortality and bring stakeholders together to adopt innovative, safe, and effective technologies that can transform cancer care.

We are a healthcare company, pioneering new technologies to advance early cancer detection. We have built a multi-disciplinary organization of scientists, engineers, and physicians and we are using the power of next-generation sequencing (NGS), population-scale clinical studies, and state-of-the-art computer science and data science to overcome one of medicine’s greatest challenges.

GRAIL is headquartered in the Bay Area of California, with locations in Washington, D.C., North Carolina, and the United Kingdom. It is supported by leading global investors and pharmaceutical, technology, and healthcare companies.

For more information, please visit grail.com

The Vice President, Clinical Development provides enterprise leadership in defining and executing GRAIL’s clinical development strategy and operations. This role defines the vision, direction, and executional framework for all clinical programs, ensuring alignment with corporate objectives and scientific priorities. The position oversees the governance and delivery of clinical studies across all phases, guiding strategic decisions that support regulatory success and product advancement. This role drives organizational excellence, cultivates talent, and represents Clinical Development in enterprise, regulatory, and external partnership settings in collaboration with relevant functions. This role is based in Sunnyvale, California. It offers a flexible work arrangement, with the ability to work from GRAIL's office or from home. Our current flexible work arrangement policy requires that a minimum of 60%, or 24 hours, of your total work week be on-site. Your specific schedule, determined in collaboration with your manager, will align with team and business needs and could exceed the 60% requirement for the site. At our Sunnyvale campus, Tuesdays and Thursdays are the key days where we encourage on-site presence to engage in events and on-site activities.

Responsibilities - Defines and executes the clinical development strategy across the portfolio, with accountability for multi-year clinical outcomes, evidence generation, development priorities, scientific integrity and regulatory compliance.

- Exercises strategic judgment in high-stakes decisions under ambiguity, anticipating emerging risks and opportunities and balancing complex clinical, scientific, regulatory, operational and financial trade-offs to optimize enterprise outcomes.

- Acts as a strategic partner with the CMO and with peers including Research, Regulatory Affairs, Medical Affairs, and Commercial to shape integrated development strategies and lifecycle plans whilst influencing enterprise wide decisions.

- Establishes and evolves the Clinical Development operating model, governance, decision-making frameworks and organizational capabilities required to execute a clinical portfolio efficiently, consistently and with high quality.

- Represents Clinical Development in executive forums, board discussions and strategic external engagements, including interactions with regulators, clinical and scientific leaders, and strategic partners, in collaboration with relevant functional leaders

- Contributes to the preparation and review of major regulatory submissions, ensuring alignment with global health authority expectations.

- Builds, leads and develops a multi-layer Clinical Development leadership organization establishing clear accountability, succession planning, leadership capability and a culture of innovation, quality and continuous improvement.

- Partners with executive leadership to define and manage clinical budgets, workforce planning, resource allocation and operational resources across the portfolio to deliver measurable business outcomes.

- Champions